In January 1823, Gleason left for the Southwest, to be a missionary to the Choctaw Indians. Alone and unmarried, Gleason found the work diffiuclt and lonely. So after three years, he returned to Connecticut, where he married Bethia, a childhood friend. Together, this new couple returned to the work among the Choctaw Indians.
The couple continued the work until 1830, when they were assigned to move back to Connecticut to work among the Mohegans Indians. They latter did work among the Seneca Indians. Anson Gleason would spend forty years of his life among the people he grew to love.
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